If you're a Family Guy fan, you've probably wondered why the hell Stewie can talk to Brian and other people, but never his family.  Seth MacFarlane has the answer, because he created the show. 

 

The question was asked at a Comic Con panel, which is where super fans get ask super fan questions like "Who Can Stewie Talk To?"  Personally, I'm not a huge fan of Family Guy, but even I admit Stewie is pretty effin funny.