There is absolutely no way I would work with a real tiger for any reason whatsoever. I have seen the videos on the internet when animals attack. However, I was cheaper for Seth Rogen to use a real tiger over digital effects. He also talks about his security disappearing one day during the movie.
It amazes me that our population is still growing to this day. Somehow, people are still doing extremely stupid things and still surviving. This person jumped into a tiger enclosure at a zoo to grab a dropped hat. Thankfully the area where the hat fell was somehow shut off to the tiger. Watching the reaction of the tiger though, he would've been killed had he jumped in the wrong place.
The chances of any of us seeing a tiger on any highway are slim and none. I would guess the only time it would happen is if the circus was in town, and one got loose. That being said in other parts of the world it can happen and did - in Qatar.